{"id":9780,"date":"2026-10-01T19:01:01","date_gmt":"2026-10-01T10:01:01","guid":{"rendered":"https:\/\/www.wakakoukai.or.jp\/rihabili\/?p=9780"},"modified":"2026-10-05T11:00:54","modified_gmt":"2026-10-05T02:00:54","slug":"paper261002","status":"publish","type":"post","link":"https:\/\/www.wakakoukai.or.jp\/rihabili\/paper261002\/","title":{"rendered":"\u9662\u9577 \u9326\u898b\u4fca\u96c4\u306e\u82f1\u6587\u8ad6\u6587\u304c\u767a\u884c\u3055\u308c\u307e\u3057\u305f"},"content":{"rendered":"

Google Scholar\u306e\u5f15\u7528\u56de\u6570\u304c15,950\u56de\u3092\u8d85\u3048\u307e\u3057\u305f\u3002<\/span><\/p>\r\n

( https:\/\/scholar.google.com\/citations?hl=ja&user=VDh7Y-MAAAAJ<\/a> )<\/span><\/p>\r\n

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\u6d0b\u96d1\u8a8c\u3000\u2015\u3000Hypertension research\u3000\u2015<\/span><\/h3>\r\n

\uff08 Springer Nature\u00a0\u767a\u884c<\/span>\uff09<\/p>\r\n

 <\/p>\r\n

Adipocyte-specific deletion of adrenomedullin exacerbates high-fat diet-induced hypertension.<\/p>\r\n

 <\/p>\r\n

Oya M, Cho K, Inazumi H, Nishikimi T, Kuwahara K, Minamino N, Nakagawa Y, Kinoshita H, Moriuchi K, Yanagisawa H, Kanamori T, Minami T, Nishi E, Kangawa K, Nakao K, Ono K.<\/p>\r\n

 <\/p>\r\n

Hypertens Res. <\/a> 2026 Sep 11. doi: 10.1038\/s41440-026-02795-2.<\/p>\r\n

 <\/p>\r\n

\uff08impact factor 5.0\uff09<\/p>\r\n

 <\/p>\r\n

\u8840\u7ba1\u4f5c\u52d5\u6027\u7269\u8ceaAdrenomedullin\u304c\u8102\u80aa\u7d30\u80de\u306b\u3082\u9ad8\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u4ee5\u524d\u306b\u5831\u544a\u3057\u3001\u305d\u306e\u75c5\u614b\u751f\u7406\u5b66\u7684\u610f\u7fa9\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u3001\u8102\u80aa\u7d30\u80de\u7279\u7570\u7684\u306bAdrenomedullin\u3092\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3057\u305f\u30de\u30a6\u30b9\u3092\u4f5c\u6210\u3057\u3001\u305d\u306e\u610f\u7fa9\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u305f\u3002\u9ad8\u5ea6\u8102\u80aa\u98df\u8ca0\u8377\u3067\u80a5\u6e80\u3068\u9ad8\u8840\u5727\u304c\u8a98\u767a\u3055\u308c\u3001Adrenomedullin\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u7fa4\u3067\u306f\u5bfe\u7167\u30de\u30a6\u30b9\u3068\u6bd4\u3079\u3066\u8840\u4e2d\u6fc3\u5ea6\u304c\u6709\u610f\u306b\u4f4e\u304f\u306a\u308a\u3001\u8840\u5727\u4e0a\u6607\u304c\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u80a5\u6e80\u6642\u306b\u8102\u80aa\u7d30\u80de\u3067\u7523\u751f\u3055\u308c\u308bAdrenomedullin\u306f\u8840\u4e2d\u6fc3\u5ea6\u306e\u5897\u52a0\u306b\u5bc4\u4e0e\u3057\u3001\u8840\u5727\u3092\u4f4e\u304f\u3059\u308b\u65b9\u5411\u3067\u50cd\u3044\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/p>\r\n<\/div>\r\n<\/div>\r\n

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\u6d0b\u96d1\u8a8c\u3000\u2015\u3000Nature communications\u3000\u2015<\/span><\/h3>\r\n

\uff08 Nature Pub. Group\u00a0\u767a\u884c<\/span>\uff09<\/p>\r\n

 <\/p>\r\n

Endothelial C-type natriuretic peptide\/guanylyl cyclase-B signaling prevents pulmonary arterial hypertension<\/p>\r\n

 <\/p>\r\n

Yanagisawa H, Kuwahara K, Nakagawa Y, Moriuchi K, Kinoshita H, Inazumi H, Kanamori T, Nishikimi T, Oya M, Nakao K, Ueda Y, Nakamura D, Shimizu K, Yoshie K, Tanaka S, Nakajima D, Sakanoue I, Yasoda A, Nakao K, Kimura T, Ono K.<\/p>\r\n

 <\/p>\r\n

Nat Commun. <\/a> 2026 Mar 17;17(1):2331. doi: 10.1038\/s41467-026-70139-2.<\/p>\r\n

 <\/p>\r\n

\uff08impact factor 18.1\uff09<\/p>\r\n

 <\/p>\r\n

CNP\u306f\u30ca\u30c8\u30ea\u30a6\u30e0\u5229\u5c3f\u30da\u30d7\u30c1\u30c9\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b\u30ea\u30ac\u30f3\u30c9\u306e1\u3064\u3067\u3001\u8840\u7ba1\u5185\u76ae\u3001\u9aa8\u3001\u8133\u304b\u3089\u591a\u304f\u7523\u751f\u3055\u308c\u308b\u3002\u4eca\u56de\u3001\u8840\u7ba1\u5185\u76ae\u7279\u7570\u7684\u306bCNP\u3092\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3057\u305f\u30de\u30a6\u30b9\u3092\u4f5c\u6210\u3057\u3001\u80ba\u9ad8\u8840\u5727\u306b\u304a\u3051\u308b\u610f\u7fa9\u306b\u3064\u3044\u3066\u691c\u8a0e\u3057\u305f\u3002\u80ba\u9ad8\u8840\u5727\u3092\u767a\u75c7\u3057\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u5448\u3055\u306a\u3044\u30de\u30a6\u30b9\u3068\u6bd4\u8f03\u3057\u3066\u3001\u80ba\u306b\u304a\u3051\u308bNPP-C\u304a\u3088\u3073NPR-B\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u305f\u3002\u80ba\u9ad8\u8840\u5727\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001\u5185\u76ae\u7279\u7570\u7684CNP\u307e\u305f\u306fNPR-B\u7279\u7570\u7684\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306f\u3001\u5bfe\u7167\u30de\u30a6\u30b9\u3068\u6bd4\u8f03\u3057\u3066\u3001\u3088\u308a\u91cd\u5ea6\u306ePH\u3092\u5448\u3057\u305f\u304c\u3001\u4e00\u65b9\u3001\u5e73\u6ed1\u7b4b\u7d30\u80de\u7279\u7570\u7684NPR-B\u7279\u7570\u7684\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3067\u306f\u3053\u306e\u3088\u3046\u306a\u5909\u5316\u306f\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002CNP\u306e\u6295\u4e0e\u306f\u3001\u5bfe\u7167\u30de\u30a6\u30b9\u304a\u3088\u3073\u5e73\u6ed1\u7b4b\u7279\u7570\u7684NPR-B\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306b\u304a\u3051\u308bPH\u306e\u767a\u75c7\u3092\u6291\u5236\u3057\u305f\u304c\u3001\u5185\u76ae\u7279\u7570\u7684NPR-B\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3067\u306f\u305d\u306e\u52b9\u679c\u306f\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002\u307e\u305f\u3001CNP\u306e\u6295\u4e0e\u306f\u3001\u5bfe\u7167\u30de\u30a6\u30b9\u304a\u3088\u3073\u5e73\u6ed1\u7b4b\u7279\u7570\u7684NPR-B\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u80ba\u9ad8\u8840\u5727\u306e\u767a\u75c7\u3092\u6291\u5236\u3057\u305f\u304c\u3001\u5185\u76ae\u7279\u7570\u7684NPR-B\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3067\u306f\u305d\u306e\u52b9\u679c\u306f\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002\u4ee5\u4e0a\u306e\u3053\u3068\u304b\u3089\u3001\u8840\u7ba1\u5185\u76ae\u306b\u304a\u3051\u308bCNP\/NPR-B\u30b7\u30b0\u30ca\u30eb\u306f\u80ba\u9ad8\u8840\u5727\u306e\u767a\u75c7\u306b\u5bfe\u3057\u3066\u91cd\u8981\u306a\u4e88\u9632\u7684\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u304a\u308a\u3001\u80ba\u9ad8\u8840\u5727\u306b\u5bfe\u3059\u308bCNP\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/p>\r\n<\/div>\r\n<\/div>\r\n

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 <\/p>\r\n

\u6d0b\u96d1\u8a8c\u3000\u2015\u3000Journal of the American Heart Association\u3000\u2015<\/span><\/h3>\r\n

\uff08 Wiley-Blackwell\u00a0\u767a\u884c<\/span>\uff09<\/p>\r\n

 <\/p>\r\n

Perspectives on C-Type Natriuretic Peptide in Cardiometabolic Disease<\/p>\r\n

 <\/p>\r\n

Goetze JP, Yanagisawa H, Kinoshita H, Burnett J Jr, Nyberg M, Nishikimi T.<\/p>\r\n

 <\/p>\r\n

J Am Heart Assoc . <\/a> 2025 Dec 16;14(24):e046011. doi: 10.1161\/JAHA.125.046011.<\/p>\r\n

 <\/p>\r\n

\uff08impact factor 6.0\uff09<\/p>\r\n

 <\/p>\r\n

CNP\uff08C\u578b\u30ca\u30c8\u30ea\u30a6\u30e0\u5229\u5c3f\u30da\u30d7\u30c1\u30c9\uff09\u306e\u6700\u8fd1\u306e\u7814\u7a76\u306e\u6d41\u308c\u306b\u3064\u3044\u3066\u7dcf\u8aac\u3067\u306e\u5831\u544a\u3092\u884c\u3063\u305f\u3002CNP\u306f\u6700\u521d\u8133\u7d44\u7e54\u306b\u304a\u3044\u3066\u767a\u898b\u30fb\u540c\u5b9a\u3055\u308c\u305f\u304c\u3001\u8840\u6db2\u5185\u3067\u306e\u5909\u5316\u306e\u7531\u6765\u306f\u4e3b\u306b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3067\u884c\u308f\u308c\u3066\u3044\u308b\u3002\u5f93\u3063\u3066\u3001CNP\u306f\u8840\u7ba1\u6a5f\u80fd\u306e\u6052\u5e38\u6027\u3092\u7dad\u6301\u3059\u308b\u5c40\u6240\u56e0\u5b50\u3068\u3057\u3066\u6349\u3048\u308b\u3079\u304d\u3067\u3059\u3002CNP\u306f\u69cb\u9020\u7684\u306bANP\u3084BNP\uff08A\u578b\u304a\u3088\u3073B\u578b\u30ca\u30c8\u30ea\u30a6\u30e0\u5229\u5c3f\u30da\u30d7\u30c1\u30c9\uff09\u3068\u985e\u4f3c\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u4e3b\u8981\u306a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306f\u7279\u7570\u7684\u306a\u819c\u7d50\u5408\u578b\u53d7\u5bb9\u4f53NPR-B\u3092\u4ecb\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001ANP\u3084BNP\u3068\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u306f\u751f\u3058\u307e\u305b\u3093\uff08ANP\u3084BNP\u306f\u819c\u7d50\u5408\u578b\u53d7\u5bb9\u4f53NPR-A\u3092\u4ecb\u3059\u308b\uff09\u3002\u305d\u306e\u305f\u3081\u3001\u5fc3\u81d3\u7531\u6765\u306eANP\u3084BNP\u304b\u3089\u306e\u5e72\u6e09\u3092\u53d7\u3051\u308b\u3053\u3068\u306a\u304f\u3001CNP\u306e\u767a\u73fe\u3084\u4f5c\u7528\u3092\u7279\u7570\u7684\u306b\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u3053\u3046\u3057\u305f\u89b3\u70b9\u304b\u3089\u3001\u6211\u3005\u306fCNP\u7cfb\u3092\u3001\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u75be\u60a3\u3001\u9ad8\u8840\u5727\u3001\u7cd6\u5c3f\u75c5\u306b\u304a\u3044\u3066\u3001\u5408\u4f75\u75c7\u3084\u5fc3\u4e0d\u5168\u306e\u767a\u75c7\u524d\u306b\u4ecb\u5165\u3092\u884c\u3046\u305f\u3081\u306e\u3001\u3053\u308c\u307e\u3067\u5341\u5206\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3053\u306a\u304b\u3063\u305f\u6a19\u7684\u3068\u3057\u3066\u63d0\u793a\u3059\u308b\u3002\u3053\u306e\u53ef\u80fd\u6027\u3092\u6700\u5927\u9650\u306b\u5f15\u304d\u51fa\u3059\u3079\u304f\u3001\u6211\u3005\u306f\u3001\u30d2\u30c8\u306ein vitro\u304a\u3088\u3073ex vivo\u7cfb\u3001\u5b9f\u9a13\u7684\u533b\u5b66\u30a2\u30d7\u30ed\u30fc\u30c1\u3001\u306a\u3089\u3073\u306b\u30d2\u30c8\u30b3\u30db\u30fc\u30c8\u30c7\u30fc\u30bf\u306e\u6d3b\u7528\u306b\u7126\u70b9\u3092\u5f53\u3066\u3001\u672c\u5206\u91ce\u3078\u306e\u95a2\u5fc3\u304c\u518d\u3073\u9ad8\u307e\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\r\n<\/div>\r\n<\/div>\r\n

\u9326\u898b\u9662\u9577\u306f\u3001\u5fc3\u81d3\u8840\u7ba1\u7cfb\u306a\u3069\u306e\u7814\u7a76\u3092\u7d04<\/span>40<\/span>\u5e74\u7d9a\u3051\u3066\u304a\u308a\u3001\u3053\u308c\u307e\u3067\u306b\u82f1\u6587\u8ad6\u6587\u3082<\/span>200<\/span>\u90e8\u4ee5\u4e0a\u767a\u8868\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>","protected":false},"excerpt":{"rendered":"

Google Scholar\u306e\u5f15\u7528\u56de\u6570\u304c15,950\u56de\u3092\u8d85\u3048\u307e\u3057\u305f\u3002 ( https:\/\/scholar.google.com\/citations?hl=ja&user=VDh7Y-MAAAAJ )   […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/www.wakakoukai.or.jp\/rihabili\/wp-json\/wp\/v2\/posts\/9780"}],"collection":[{"href":"https:\/\/www.wakakoukai.or.jp\/rihabili\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wakakoukai.or.jp\/rihabili\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wakakoukai.or.jp\/rihabili\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wakakoukai.or.jp\/rihabili\/wp-json\/wp\/v2\/comments?post=9780"}],"version-history":[{"count":10,"href":"https:\/\/www.wakakoukai.or.jp\/rihabili\/wp-json\/wp\/v2\/posts\/9780\/revisions"}],"predecessor-version":[{"id":9790,"href":"https:\/\/www.wakakoukai.or.jp\/rihabili\/wp-json\/wp\/v2\/posts\/9780\/revisions\/9790"}],"wp:attachment":[{"href":"https:\/\/www.wakakoukai.or.jp\/rihabili\/wp-json\/wp\/v2\/media?parent=9780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wakakoukai.or.jp\/rihabili\/wp-json\/wp\/v2\/categories?post=9780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wakakoukai.or.jp\/rihabili\/wp-json\/wp\/v2\/tags?post=9780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}